The composition has a pyramidal shape inspired by the works of Leonardo da Vinci, with an emphasis on the plasticity of the figures and the articulation of them in space. At the top San Giuseppe, leaning on the cane, serenely watches over the Madonna and Saint Elisabetta, sitting on a lawn and holding their respective children, Jesus and John the Baptist.

In this work Raphael increased the number of characters, looking for refined poses in formal correspondences, with curvilinear rhythms that knot and melt continuously, both on the surface and in depth. In fact, looks and gestures are cleverly intertwined, in an extremely studied complex but with an extremely simple and natural effect, with a serene and calm tone.

The landscape that is lost in depth has Venetian characters of atmospheric interpenetration, as well as the rich palette, bright colors, that reminds Giorgione.